ForecastedNational Institutes of Health

NIH Director's Transformative Research Award (R01 Clinical Trial Optional)

Opportunity number RFA-RM-28-003 · Assistance listing 93.310

Estimated deadline
Sep 3, 2027
Expected posting
Sep 3, 2026
Award size
Not listed
Total program funding
Not listed
Expected awards
6
Cost sharing
Not required
Funding type
Grant
Category
Health
NIH R01: recently funded projects, typical award sizes and top institutions

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About this opportunity

The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program.

Who can apply

  • Public and Indian housing authorities
  • Independent school districts
  • Nonprofits with 501(c)(3) status
  • Federally recognized tribal governments
  • City or township governments
  • Private universities
  • Nonprofits without 501(c)(3) status
  • Other (see eligibility)
  • County governments
  • State governments
  • Small businesses
  • Special district governments
  • For-profit organizations
  • Other Native American tribal organizations
  • Public and state universities

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Agency contact

NIH Director's Transformative Research Award Program

Please contact via email.

Transformative_Awards@mail.nih.gov
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Details from Grants.gov, last updated Sep 3, 2026. Deadlines and requirements can change: always confirm them in the official notice.