ForecastedNational Institutes of Health

Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)

Opportunity number RFA-RM-28-017 · Assistance listing 93.310

Estimated deadline
Jul 1, 2027
Expected posting
Sep 14, 2026
Award size
Not listed
Total program funding
Not listed
Expected awards
Not listed
Cost sharing
Not required
Funding type
Grant
Category
Health

Check this solicitation free

Grantee reads the full announcement and lists every required section, page limit, deadline, scoring criterion and compliance item. Takes about two minutes, no account needed.

About this opportunity

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from standardized human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO)supporting Stage 2 of the SMaHT Experimental and Computational Technology Development initiative. The Experimental and Computational Technology Development initiative supports multidisciplinary development, optimization, validation, benchmarking, and dissemination of rigorous, cost-effective technologies for somatic mutation detection and functional interpretation.

Awardees will collaborate with other SMaHT Stage 2 initiatives to incorporate validated technologies into production workflows, pipelines, data releases, and community resources.

Who can apply

  • For-profit organizations
  • State governments
  • Nonprofits without 501(c)(3) status
  • Special district governments
  • Federally recognized tribal governments
  • Other (see eligibility)
  • Private universities
  • County governments
  • Public and Indian housing authorities
  • City or township governments
  • Small businesses
  • Independent school districts
  • Nonprofits with 501(c)(3) status
  • Public and state universities
  • Other Native American tribal organizations

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Agency contact

SMaHT Program

Please contact via e-mail.

smaht@od.nih.gov
Write this proposal with Grantee
  • Reads the full solicitation and lays out every required section
  • Drafts each section with you, in your words
  • Checks the draft against every requirement before you submit
Official notice on Grants.gov

How to write it

All guides

More from NIH

All NIH funding

Get new funding every Monday

New federal opportunities and upcoming deadlines for NIH and more, in one short email. Free, unsubscribe anytime.

Details from Grants.gov, last updated Sep 14, 2026. Deadlines and requirements can change: always confirm them in the official notice.